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产品名称:Rabbit antibody to c-terminal 英文名:
CAS: 参?#25216;?#26684;:
规格:100 µl 产地:osenses 货号:OST00053W
产品简介:Rabbit antibody to c-terminal of human Telomerase reverse transcriptase (TERT): whole serum,OST00053W,osenses

Rabbit antibody to c-terminal of human Telomerase reverse transcriptase (TERT): whole serum

Code OST00053W
ID Tag Rb410-200308-WS

Unit size 100 µl
Immunogen A synthetic peptide from c-terminal of human Telomerase reverse transcriptase (HEST2, TP2, TERT, EST2, TCS1, TRT) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate Unconjugated antibody
Accession TERT_HUMAN
Also known as Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT
Background FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
SUBCELLULAR LOCATION: Nucleus. Telomere.
DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis.
Host NZ white rabbit
Purity Whole serum
Clonality Polyclonal
Isotype Polyclonal, whole serum
Applications IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity Specific for TERT.
Spcs X-react. Human. Other species not yet tested.
Format Lyophilised
Reconstitution Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months after reconstitution
Transportation This item will be shipped to you at ambient temperature in a lyophilised form.
References 1. Nakamura T.M, et al. Science 277:955-959(1997).
2. Meyerson M, et al. Cell 90:785-795(1997).
3. Wick M, et al. Gene 232:97-106(1999).
4. Hisatomi H, et al. Neoplasia 5:193-197(2003).
5. Tsakiri K.D, et al. Proc. Natl. Acad. Sci. U.S.A. 104:7552-7557(2007).
6. Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Limitation For research use only


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